The effect of hypoxia on the developing brain: A function of age

Introduction: In evaluating neonatal resuscitation practices, the use of 100% oxygen for resuscitation of asphyxiated infants has been questioned. Evidence in animal models has determined that exposure to hyperoxia during and after the hypoxic period can generate excessive neurotoxic compounds and that resuscitation with room air may result in better neurologic outcome. Two controlled clinical trials concluded that there was no difference in mortality whether the infants were resuscitated with room air or with 100% oxygen. We hypothesized that there are age related differences in oxygen’s effect on neurodegeneration in the developing brain.